Background: An
employee (Worker X) of a fast food restaurant located in a hospital was
admitted with pneumonia. He complained of cough for one year and a
ten-pound involuntary weight loss. Objective: To describe
the use of IGRA in contact investigation among coworkers exposed to Worker X.
Methods: An
epidemiologic investigation was performed by the hospital's infection control
department and the Results: Four of 11 (36%)
household and family contacts had reactive TST with normal chest radiographs,
and offered isoniazid (INH) therapy for latent
tuberculosis infection (LTBI). None of the 42 coworkers were symptomatic
(mean age of 29.8 years, range 17-59 yrs). There were three (7%) who had
positive IGRA at baseline with negative chest radiographs and one (2%) coworker
who had an indeterminate IGRA result. Of the 38 who had negative IGRA tests at
baseline, 33 had follow-up testing done. Only one of these 33 (3%)
coworkers converted at 10 weeks, with a negative chest radiograph. All workers
with positive IGRA received INH therapy for LTBI. One of the four (25%)
coworkers on the same shift as Worker X had a positive IGRA test versus three
of thirty eight (8%) who did not work on the same
shift (p=0.3, two-tailed Fisher's exact test). There were no
identified cases of active tuberculosis (TB) linked to Worker X, who is doing
well with clinical and radiographic improvement, and completing 9 months of
therapy.
Conclusions: A case of
pulmonary TB in a fast food worker may have accounted for 10% transmission of
infection among coworkers. IGRA testing was an efficient method for obtaining
baseline and follow-up assessments of TB infection in this relatively young,
mobile population.