Paul C. Johnson, MD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Hardik Doshi, MBBS
,
Detroit Medical Center, Wayne State University, Detroit, MI
Jing J. Zhao, PharmD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Jason M. Pogue, PharmD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Kayoko Hayakawa, MD, PhD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Odaliz Abreu-Lanfranco, MD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Sapna Parmar
,
Detroit Medical Center, Wayne State University, Detroit, MI
Dror Marchaim, MD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Sorabh Dhar, MD
,
Detroit Medical Center, Wayne State University, Detroit, MI
Keith S. Kaye, MD, MPH
,
Detroit Medical Center, Wayne State University, Detroit, MI
Background: AB is a hospital pathogen that has
become increasingly common in hospitals. Scant data exist regarding the
factors predictive of BSI due to
AB in hospitalized patients.
Objective: The objective of this study was to analyze
risk factors for BSI due to
AB.
Methods: A retrospective matched case-control study
including 245 episodes of AB BSI
and 245 matched controls without infection. The study was conducted at the Detroit Medical Center
and included patients cared for from January 2006 to April 2009. Patients with positive blood cultures for AB
were identified from laboratory data.
Controls were matched to case patients in a 1:1 ratio based on admitting
hospital, admitting unit, and at-risk period (time admission to positive
culture date for cases). Patient
variables collected included demographics, comorbid
conditions, antibiotic exposure, surgeries, mechanical ventilation, central
lines, Foley catheters, and inpatient mortality. Antibiotic exposure in cases
was defined as administration of an antibiotic from thirty days prior to
culture date up to one day prior to culture date. In controls, antibiotic exposure was defined
as administration of any antibiotic from thirty days prior to discharge up until
discharge. Logistic regression was used
to identify independent risk factors for BSI
due to AB.
Results: Mean age of the case and control cohorts was
55±24 and 55±24 (p=0.6). 47% of
cases and 52% of controls were male (p=0.23). Seventy-three % of cases
and 81% of controls were African-American (p=0.04). The median Charlson's
comorbidity index was greater in cases (4, IQR 2-8)
than in controls (0-4) (p<0.0001).
60% of cases were admitted from home compared to 90% of controls (p<0.0001).
The following variables, excluding antibiotics, were
statistically significant in multivariate analysis (Table).
Risk Factors | Odds Ratio (95% CI) | p-value |
Central Line Placement | 6.1 (2.68-14.22) | <0.0001 |
Foley Catheter Placement | 0.4 (0.20-0.88) | 0.02 |
Serum Albumin < 2.5 g/dL | 0.1 (0.06-0.26) | <0.0001 |
When
antibiotics were added to the model, the following were associated with aquistion of BSI due to AB: carbapenems
(OR 5.3 [2.21-12.56], p=0.0002), colistimethate
(OR 3.9 [1.08-14.24], p=0.04) and use of β-lactams including β-lactams/β-lactamase-inhibitor
(BLABLI) (OR 1.7 [0.99-2.86], p=0.05).
Conclusions :
Exposure to various broad spectrum antimicrobials, including carbapenems, colistimethate, and
β-lactams/BLABLIs were each strongly associated
with acquisition of BSI due to AB.