94 National Clostridium difficile Infection (CDI) related hospitalizations approaches MRSA related hospitalizations-The need for antibiotic stewardship programs

Saturday, April 2, 2011
Trinity Ballroom (Hilton Anatole)
Teena Chopra, MD , Detroit Medical Center, Wayne State University, Detroit, MI
Dror Marchaim, MD , Detroit Medical Center, Wayne State University, Detroit, MI
George Alangaden, MD , Detroit Medical Center,Wayne State University, Detroit, MI
Keith S. Kaye, MD, MPH , Detroit Medical Center, Wayne State University, Detroit, MI
Tom Taylor, PhD , Detroit Medical Center, Wayne State University, Detroit, MI
Background: According to previous studies, the national incidence of adult CDI hospitalizations doubled from 5.5 cases per 10,000 population in 2000 to 11.2 in 2005. Previous studies have reported CDI related hospitalizations to be 291,303 in the year 2005. However, no studies have looked at more recent national CDI related hospitalizations.

Objective: To compare CDI related hospitalizations to MRSA related hospitalizations from National Healthcare Cost and Utilization Project (HCPUP) data in 2007.

Methods: Data from the 2007 HCPUP, Nationwide Inpatient Sample (NIS) were analyzed to identify CDI-associated hospitalizations.  All hospitalizations with a diagnosis of CDI (ICD-9 code 8.45) were defined as CDI-associated hospitalizations. The HCUP-NIS data represents a stratified sample of approximately 20% of non-federal community hospitals in the US and were weighted for national projections. We utilized HCUP data to calculate national estimates of CDI and MRSA related hospitalizations in the year 2007.

Results: Of the total 39.5 million hospitalizations in the year 2007, 325,022 cases of CDI and 420,153 MRSA-associated hospitalizations were seen. This translates into 0.8% and 1.1% of hospitalizations respectively. The CDI related hospitalizations in 2007 increased to 325,022 cases as compared to 291,303 cases of CDI related hospitalizations in the year 2005, an increase of 11.6 % in 2 years.

Conclusions: With this concerning rise in national CDI related hospitalizations and in the face of aging population ,there is a critical need for strong antibiotic stewardship programs in the country to face this growing challenge.